Showing posts with label Chinese Medicine. Show all posts
Showing posts with label Chinese Medicine. Show all posts

Friday, September 10, 2010

Can Chinese Herbs Treat Cancer?

Scuttelaria Barbata, Ban Zhi Lian
The Chinese herb Ban Zhi Lian may not be in everyone's lexicon, but to the 80 women with stage IV metastatic breast cancer, who are participating in the second phase of the BZL101 clinical trials, it represents hope and life.
For Bionovo, the drug discovery and development company in Emeryville, Calif., that's behind BZL101, there's hope too. The trial is the first FDA-validated clinical study of a potential cancer drug derived from a Chinese medicinal herb, says Dr. Mary Tagliaferri, a co-founder of the company, former practicing acupuncturist and a breast-cancer survivor. "Sixty-two percent of chemotherapy drugs come from natural products, and plants have been the basis of almost every new class of medication," she says. "It makes sense that these plants can act as anticancer agents."  For the whole story follow this link to Time Magazine.


Alex's Note:  This research is promising and important to validate Traditional use of Chinese herbs for cancer.   To be clear the way they are using the herb is in high-dosages as a single agent. 
Traditional Chinese Medicine uses multiple herbs in concert generally in lower doses and has for centuries.  I imagine that as the research on this herb goes forward they will eventually get away from the whole herb to use the extracts that are the most active against cancer.  This is where the patentable drugs can be derived.  That is good but part of the uniqueness of an herb like this one is that there toxicity profile is extremely low as a whole herb.  That will most probably not remain when it becomes a refined drug.  However as an anticancer pharmaceutical drug it will probably be more effective than the whole herb. 

As I have written about in previous posts, there are many times when anti-cancer herbs and formulas can be appropriately used within the context of conventional therapies.  Througout most of my chemotherapy I took this herb in a formula in conjunction with chemotherapy and radiation.   This is how it is done in China - combining east and west.  

More Information about the study:
http://www.bzl101.com/

Deeper understanding of the herb on the Sloane Kettering Herbal Database 
Article for practitioners from Subuthi Dharmananda on Bai Hua She She Cao (Oldenlandia)  and Ban Zhi Lian (Scutellaria)

Thursday, November 19, 2009

The Use of Chinese Herbs With Radiotherapy



By Alex Berks L. Ac. Dipl. Herbs, FABORM
Clinical Director of Chinese Medicine Oncology



Integrating Chinese herbal medicine with conventional radiotherapy can be of immense benefit to a cancer patient. In the scientific literature it is reported across many studies from China that the integration of both medicines is better than either one alone.

This article addresses the prescription of Chinese herbs for a radiation patient. Chinese Medicine includes acupuncture, qi gong, tai qi, massage and diet therapies, all of which are of great value to a cancer patient.

Radiation therapy can injure surrounding healthy tissue, damage fragile mucosal barriers in the lungs and intestines, injure salivary production, cause digestive problems, dryness, inflammation and even scorching depending on location, intensity and duration of the treatment. Radiotherapy can also injure the bone marrow. While the targeting of radiation therapy has vastly improved to protect surrounding tissue, radiation therapy is still a significant challenge.

From a Chinese Medicine perspective the heat from radiotherapy that is intense enough to destroy tissue generates a "toxic heat". Cancer is itself a toxin. Radiotherapy is a toxin to fight a toxin.

Herbs that rebalance the body can prevent side effects of radiotherapy, restore health and vitality, and prevent relapse and metastasis. Rebalancing is a concept of Chinese Medicine that is a fabulous complement to the cure seeking of Western Medicine.

Rebalancing against radiation toxicity is done along a continuum of signs and symptoms. For example, toxic heat depletes the moistening properties of the blood and injures the mechanisms of energy production. Then the body, in an effort to compensate for the heat, dryness and depletion of fluids, produces phlegm as a substitute lubricant. This phlegm, when combined with heat, can injure the elimination pathways in the bladder and large intestine, stagnate and deplete the blood and cause further weakness. At late stages the vital essence is injured and there is very poor energy production and compensation. Applying Chinese Medicine diagnostic principles and appropriate treatment at each stage is a way to prevent this degeneration and many side-effects.

Research has also shown that Chinese herbs improve the sensitivity of the tumor to radiotherapy.
A tumor's sensitivity to radiation is in part dependent on blood supply and oxygenation of the tissues. Herbs can improve both. It is reported that tumors have a ratio of anoxic cells which have poor radiation sensitivity. Radiation therapy may reach only about 1/3 of cells with a low oxygenic state. Low tumor infiltration by radiation is considered one of the factors causing cancer relapse.


Research studies done on single herbs, though not representative of how herbs are most beneficially applied, are illustrative of the efficacy and principles of multi-herb formulas. An example of this is a study done on a Liguistrazine extract of the common Chinese herb Chuan Xiong (Radix Liguistici Wallichi). This herb is known in the Chinese pharmocopeia as a blood activator. The results of this study showed that the rats responded to the herbal extract with increased microcirculation in caliber, flow speed, flow status and capillary count. It is not hard to see that a formula with this and other synergistic herbs could improve the microcirculation of peri-tumor tissue and the tumor body, increase blood perfusion in the tumor body, improve cell's anoxic state and could elevate the sensitivity for tumor tissue to radiation therapy. (1)

The following studies demonstrate the value of Chinese Herbal Medicine (CHM) in conjuction with radiotherapy (RT) to improve survival rates, lessen the impact of depletion of white blood cells, and improve the ability to finish the full course of treatment.

This study from Chinese Academy of Medical Sciences included 197 nasopharyngeal cancer patients who were treated with Chinese herbs plus radiation therapy compared to radiotherapy alone. The combined therapy group had twice the number of patients survive to five or more years than the radiotherapy alone group. The tumor was killed in more patients in the combined therapy group and the remote metastatic rate was less in the combined group. These findings imply that Chinese herbal medicine could enhance the radiosensitivity of tumors. (2)



Survival Rate N =197

1 year
3 Years
5 years
CHM + RT
91.3%
67.4%
52.4%
RT
80%
33.3%
24%

Disappearance of the tumor
CHM + RT
95.7%
RT
88.6%

Cause of Death
Primary lesion relapse or metastatic lesions
CHM + RT
34.8%
RT
52.4%


In another study researching the efficacy of herbs to prevent and treat side effects of radiation therapy, 71 patients were in an active treatment group with herbs and radiation and the control group was given a placebo herbal formula plus radiation.
The results showed 84.5% were able to finish the full course of radiotherapy versus 63.3% in the control group. The type and staging of the cancer was not revealed.(3)

In another small study, white blood cell counts did not go as low in a combined treated group as they did with radiotherapy alone. One particular formula Fu Zheng Xiao Formula (FZZX), was shown to moderate T-lymphocyte subset. (4)

Another combined herb-radiation study was conducted with nasopharyngeal cancer patients who continued taking herbs for 6 months after the radiation was finished. The 5 year survival rate was 75%. The authors indicate that Chinese medicine combined with radiation improved the effectiveness of radiation therapy while minimizing its toxicity in both the short and long term. In this study there was no mention of a control group. (5)

Mice studies have also showed improved efficacy when radiation and herbs were combined both on white blood cell counts and survival rate. Interestingly, the survival rates were even higher in the mice that were given the herbal mixture 1 week before beginning treatment with radiation. (6)

Many studies, repeatedly show that Chinese herbal medicine formulas can be combined efficaciously and safely to improve life expectancy and prevent adverse side effects of radiation treatment. Herbs should be started 1 week before starting radiotherapy and continue for at least 6 months after treatment to achieve maximum benefit.

Please consult with a trained Chinese Medicine practitioner who is knowledgeable in the integrative support of cancer recovery.


Footnotes:

2. Donald Abrams, Andrew Weil, Integrative Oncology (New York: Oxford University Press, 2009) chapter 13 p. 269.

3. Zhang Dai-Zhao p. 83.

4. Zhang Dai-Zhao p. 83.

5. Zhang Dai-Zhao p. 85.

6. Zhang Dai-Zhao p. 86.




Sunday, May 03, 2009

Chinese Herbs for Cancer

Alex Writes: This article is a good overview of the TCM approach to cancer treatment.


Chinese herbalists have been medicating patients with tumors for over two

thousand years. 1 In stark contrast to Western oncology concepts that undergo

constant revision, Chinese medical ideas about tumor pathogenesis and herbal

responses have remained largely the same over the centuries.2 Still, though,

Traditional Chinese Medical (TCM) approaches hold strong attraction for human

oncology patients and people whose animals have cancer.3 TCM practitioners

shun the image of “waging war on cancer” and instead embrace the more

peaceful and organic view of cancer as a journey, regarding the patient not as a

battlefield but as a garden to be nurtured.4 5 6

The enormous draw of Chinese medicine and other traditional medicine practices

led the World Health Organization to consider ways to best study the

effectiveness and safe implementation of CAM methods in clinical practice. In

response, they formulated the Traditional Medicine Strategy 2002-2005.7 In the

same year, the White House Commission published a Complementary and

Alternative Medicine Policy.8 Both organizations urged researchers to

investigate the claims and practices of long-held belief systems and empirically

derived treatments. The National Cancer Institute now recognizes that

following the leads laid by longstanding tradition will generate higher yields than

searching for cancer-fighting botanicals de novo.9 Even the Chinese Society of

Traditional Veterinary Science in Taiwan and the Asian Society of Traditional

Veterinary Science have sounded calls for more research and education in

Traditional Chinese Veterinary Medicine (TCVM) and, specifically, in herbal

prescribing.10

The assortment of Chinese herbal treatments being promoted for animal patients

with cancer is growing. Testimonials asserting reductions in tumor size in dogs

who received Chinese herbs further stoke enthusiasm and hopes of finding an

alternative cure.11 12 13 However, rather than basing the herbal prescription on

tumor type or biopsy results, herbs are matched to a patient’s disease “pattern”,

which sorts patients into groups according a system based on visible signs on

the body, the specifics of which are unique to TCM.14

TCM holds that tumors and cancer arise from emotional stress, overwork, poor

nutrition, invasion of pathogens, and poor circulation.15 16 Of these, impaired

circulation ranks as perhaps the most strongly linked etiologic factors leading to

cancer and metastasis.17 18 From a Chinese medicine perspective, the poor

circulation associated with the “blood stasis” pattern will not only deprive tissue of

vital oxygen, absorbed nutrients, and immune surveillance, and it also leads to

the buildup of metabolic end-products in the tissues. Modern oncology resonates

with this perspective at least in part, acknowledging that the microcirculation

within tumors can be abnormal and contain areas of sluggish perfusion.

Furthermore, some researchers have added anticoagulants to chemotherapy

agents in order to lengthen survival and prevent blood-borne metastasis.19

Tuesday, August 07, 2007

Complementary Medicine and Cancer

WebMd.com seems to really like acupuncture based on the idea that it can do very little (to no) harm and has some positive research. The complex topic of herbs with cancer they do not look on favorably. This is not surprising given the fact that there is so much misinformation and fear/caution about herbal treatments with cancer patients. When I work with a cancer patient I am communicating with the patients' doctor so as not to interfere with conventional treatment and keep the Dr. apprised of what may be helping the patients. There are however, many "non-interfering" periods of cancer treatment where complimentary can be of use.


Acupuncture can be used nearly all the time. Although there is a theoretical caution about using acupuncture when white blood cell counts are low due to possible risk of infection.

Herbs, supplements can be used for a cancer patient safely when prescribed properly in all the following situations
  • Before and during intervals of conventional treatment
  • When a patient is not receiving treatment
  • During conventional treatment to relieve side effects. The research seems mostly weak describing ways to take supplements to improve chemotherapy treatment efficacy.
  • pre surgery preparation, recovery from surgery
  • Post treatment side effects
  • prevention
Treating a cancer patient with herbs and acupuncture is not just about treating cancer. By law I am not allowed to do this. However, within the diagnositic scope of my License as a California Acupuncturist I diagnose blood stagnation, phlegm accumulation, organ imbalances and other variations. The remarkable thing is that this approach to balancing the body that is germane to Chinese Medicine has tremendous benefit to patients and has for a very long time. While the oncologist tends to be focused on disease, I am focused on balancing the patient. Both have a place in the care of cancer patients. Alex


Also called alternative medicine, is the complementary approach a new model for Western medicine?
By R. Morgan Griffin
WebMD Feature
Reviewed by Louise Chang, MD

A few years ago, if you asked your oncologist for a referral to a masseuse, she'd think you were joking. But things have changed. Nowadays, your oncologist might be prescribing the massage -- along with acupuncture, herbs and other therapies.

It's a sign of a new trend: complementary medicine (also called integrative medicineintegrative medicine) is making its way into the mainstream, combining standard medical treatments with complementary ones. Some hospitals have even set up entire integrative medicine centers -- largely because of patient demand.

"Patients love it," says Simone Zappa, RN, an administrator in the Integrative Medicine Department at Memorial Sloan-Kettering Cancer Center in New York. "And they love it because it works."

Complementary treatments help many people with cancer. Massage, acupuncture, and hypnosis are being used along with radiation, chemotherapy, and surgery. These complementary therapies aren't usually intended to treat the cancer itself. But they can ease side effects and improve quality of life. They may even reduce the amount of medicine you need for treatment.

What's more, some of these treatments have been shown to work in scientific studies. The gulf between evidence-based Western medicine and traditional therapies is not as wide as it once was. And many people with cancer are benefiting.

Understanding Complementary Medicine

Complementary medicine includes dozens of treatments that have not been generally used in Western medicine. They extend from nutritional changes, to biofeedback, to yoga.

Experts stress that complementary or integrative medicine is not the same as "alternative medicine." Complementary medicine for cancer is a complement -- not a replacement -- for traditional treatments like radiation, chemotherapy, and surgery. It's an important distinction, since only conventional therapies have been shown to fight cancer.

People with cancer seek out complementary medicine for many reasons. Zappa says that, at Sloan-Kettering, she most often sees people suffering from pain, nausea, depressiondepression, anxiety, and fatiguefatigue. Some are wary of the unusual approach at first. But most are convinced after they try it, says Zappa. "What's great about the integrative approach is that it gives back a feeling of control."

Complementary Medicine's New Converts

For hardened skeptics, phrases like "traditional healing techniques" and "alternative medicine" conjure up images of magic crystals and the smell of incense. But in fact, the people researching complementary medicine -- and sometimes even practicing it -- are likely to be wearing lab coats.

"The people doing this work are not crackpots," says Heather S. Shaw, MD, co-director of the Integrative Oncology Program at Duke University. "I'm an oncologist and I spend a lot of my time parked on a laboratory bench doing research."

Indeed, hospitals with complementary medicine divisions are spearheading research. Experts are using the same rigor in evaluating complementary therapies that they would in testing drugs or surgery. It's not enough to assume that a treatment works just because it's been used for thousands of years. Doctors want evidence.

After seeing the benefits of complementary medicine, many doubting oncologists have been convinced.

"My colleagues used to think I was nuts," Shaw says. "They teased me about prescribing so-called 'herbs and spices'." But now her fellow doctors are always asking her advice on new ways to help their patients.

The Integrative Approach: Is It Proven?

Of course, here's the big question: do we know if complementary medicine really works?

The answer: It depends on the specific treatment. Acupuncture and massage -- which not so long ago were considered pretty far-out -- have been shown to help. Many studies have shown that acupuncture eases chemotherapy nausea, while other studies suggest acupuncture and massage may reduce pain from cancercancer or its treatment.

"A lot of oncologists don't see acupuncture or massage as 'alternative medicine' anymore," says Shaw. "These therapies are so well established that they've become standard."

Other complementary techniques aren't as well researched. So when a treatment is unproven, the question is whether its potential benefits outweigh its risks. If it's risky, it isn't used. But if the risks are very, very low, doctors may be more open.

"If a treatment is safe but unproven, why not give it a try if the patient is interested?" says David S. Rosenthal, MD, medical director of the Center for Integrated Therapies at the Dana Farber Cancer Institute.

Things get trickier with herbal and botanical supplements. Despite their wide popularity, few have been shown to be either safe or effective against cancer. On the other hand, some have been shown to be both ineffective and unsafe. One example is laetrile, which contains a substance found in the pits of some fruits. The active ingredient seems to be cyanide, and it has resulted in symptoms of cyanide poisoning. Some common supplements -- like St. John's wort and high doses of vitamin C -- can interact with chemotherapy and radiation.

"You have to be very careful with botanical and herbal supplements," says Zappa. "They are real drugs and we just don't know a lot about them." She hopes future research will show benefits. But for now, she and other experts urge caution. Given the risks, your doctor must know about all of the herbs, botanicals, and supplements you use.

Will My Insurance Pay for Complementary Medicine?

By and large, insurance companies don't cover complementary care. Specifics vary with each insurer and from state to state. For instance, acupuncture is covered in some states but not others, says Rosenthal.

For now, most complementary medicine is provided on a fee-for-service basis. But advocates of integrative medicineintegrative medicine say this is likely to change.

"A lot of us are doing research now that, we hope, will show the benefits of these therapies," says Rosenthal. "Once we have the evidence, we can make a case to the insurance companies."

Shaw agrees. "We're hoping to show that these treatments will actually save insurers money," she says. "They may reduce hospitalizations and drug costs."

Finding a Complementary Medicine Caregiver

A lot of people may offer "complementary medicine." But how do you know if they're reputable? It's hard to be sure.

You're lucky if you live near a teaching hospital with a complementary or integrative medicine center. Many offer complementary services right in the hospital. If you're not close to such a center, talk to your doctor. He or she may know of people practicing complementary medicine in your area.

You should also look for credentials. For instance, acupuncturists should either have an LAc or be a Doctor of Oriental Medicine, says Shaw. You can see if your state licenses acupuncturists and other providers. The National Center for Complementary and Alternative Medicine has tips for finding qualified caregivers.

Shaw has two rules of thumb when judging good complementary medicine providers. First, they will not make any claims to cure cancercancer. Second, they will not try to convince you to stop conventional therapy. If a practitioner does either, you should find someone else.

There's also the flip side. If you are interested in complementary therapies, it's important your oncologist be open to them. Not every doctor is. Some flat out demand that their patients stop using all complementary therapies, since they don't know enough about them, says Shaw.

"If you want complementary therapies and your oncologist is adamantly opposed to them, you might want to find someone else," says Shaw. "There are a lot of open-minded oncologists out there who will help you."

But Zappa predicts that opposition to integrative medicine will become more and more rare.

"People in medicine are scientists, and scientists rightly need proof that treatments work," she tells WebMD. "But now we finally have a lot of good research coming out. Once the research is out there, no one can ignore it. These treatments really do help people feel better."

WebMD Feature

Published Oct. 23, 2006.SOURCES: American Cancer Society web site, "Complementary and Alternative Therapies." Corbin, L. Cancer Control, July 2005; vol 12: pp 158-164. Memorial Sloan-Kettering Cancer Center web site, "Individual Therapies." National Cancer Institute, "Acupuncture PDQ," "Complementary and Alternative Medicine in Cancer Treatment: Questions and Answers." David S. Rosenthal, MD, professor of medicine, Harvard Medical School; medical director, Leonard P. Zakim Center for Integrated Therapies at the Dana Farber Cancer Institute, Boston. Heather S. Shaw, MD, assistant professor of medicine, Multidisciplinary Breast Program, Duke University Medical Center. Simone Zappa, RN, administrator, Integrative Medicine Department, Memorial Sloan-Kettering Cancer Center, New York. U.S. Department of Health and Human Services, "Thinking about Complementary and Alternative Medicine."
©2005-2007 WebMD, Inc. All rights reserved.
WebMD does not provide medical advice, diagnosis or treatment.

Sunday, July 15, 2007

TCM helps Lung Cancer Patients in conjunction with Chemo.

Ai Zheng. 2005 Oct;24(10):1252-6.Related Articles, Links
Click here to read
[Prognostic analysis of stage III-IV non-small cell lung cancer patients treated by traditional chinese medicine]


Zhou DH, Lin LZ, Zhou YQ, Luo RC, Liu KF, Jia YJ, Chen JY, Niu XW, Su BR, Lu J, Wang ST.

Cancer Center, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, P. R. China. zdh@oncology.org.cn

BACKGROUND & OBJECTIVE: Chemotherapy is a treatment for stage III-IV non-small cell lung cancer (NSCLC), but the efficacy is not ideal. Traditional Chinese medicine (TCM) has certain effect on NSCLC. This study was to investigate various factors that affect the prognosis of advanced NSCLC, and evaluate the role of TCM in enlonging survival time of patients with stage III-IV NSCLC. METHODS: The NSCLC patients who meet the inclusive criteria were randomized into TCM group, combination (TCM plus NP regimen) group, and chemotherapy group, and received relevant treatments. The median survival time (MST) was calculated by Kaplan-Meier method. The prognosis of the patients was analyzed by COX regression method. RESULTS: A total of 294 stage III-IV NSCLC patients were enrolled, of which 99 were in TCM group, 103 in combination group, 92 in chemotherapy group. The MST were 292 days in TCM group, 355 days in combination group, and 236 days in chemotherapy group; the cumulative survival rates were 45.38%, 48.86%, and 42.17%, respectively (P>0.05). Cox regression analysis indicated that therapy, gender, disease course, erythrocyte sedimentation, KPS score, tumor size, and patient's weight were independent prognostic factors of stage III-IV NSCLC. CONCLUSION: Compare with chemotherapy alone, TCM combined with chemotherapy may prolong the survival time of stage III-IV NSCLC patients.

Publication Types:

Friday, January 12, 2007

Cancer Treatment from the Chinese Medicine Perspective

This article comes from a new (and free) online journal Chinese Medicine Times. It is an overview of how the author sees Chinese Medicine as offering help cancer to cancer patients
What can we offer as practitioners of Chinese medicine? This is dependent upon our expertise as practitioners but also on the person who seeks help. For example, some people merely request alleviation of symptoms caused by conventional medical treatment. Other people involve themselves much more in their Chinese medical treatment, look at their diets and take up internal exercises such as tai chi or qi gong. Some completely eschew conventional treatment and seek only support and treatment from holistic medicine, either Chinese medicine or a combination of different therapies. I have observed, over the past 20 years or so in practice, that increasing numbers of people are actively questioning their treatment options and are moving towards holistic methods, either in conjunction with conventional treatment or alone.