Showing posts with label Herbs with cancer. Show all posts
Showing posts with label Herbs with cancer. Show all posts

Monday, October 31, 2011

Think Different - The Medical Lesson of Steve Jobs’ Cancer

Apple had a wonderful advertising campaign which featured historical footage of great figures who thought different and changed history (link here to see advert.). For all of Steve Jobs' creative genius and drive his amazing ability to “think different” didn’t seem to serve him in his own health care.  There is a lesson here for us all.  

It is reported that Jobs died from a rare, less aggressive type of pancreatic cancer called an islet cell neuroendocrine tumor.  This potentially could have been treated successfully with surgery.  He opted for acupuncture, herbs, and a vegan diet for 9 months rather than surgery because, according to his biographer, he did not want to be cut open.  Even Steve Jobs later regretted his decision not to choose surgery sooner. (See Forbes Magazine:  Steve Jobs Cancer Treatment Regrets)

There is an implication in this story that acupuncture, herbs and dietary changes are bad for cancer patients, and that if Steve Jobs would have just listened to his doctor he may have been cured.  This needs to be clarified. 
 
Common sense is not always so common.  Choosing natural cancer treatments over toxic or highly invasive treatments has a role, but it is generally not at the beginning stages of cancer treatment, when there is curative intent.  Conventional cancer therapies may be improved with greater insight into drugs, cancer growth pathways and the ways both natural and pharmaceutical work against cancer growth.  It must be emphasized there is scientific literature on the synergistic collaboration between natural and pharmaceutical cancer therapies, not just the potential of bad herb drug interactions.  (footnote)

Had Mr. Jobs opted for surgery, the role of natural medicine could have been to get him ready for surgery, help him recover, and then analyze tumor pathology, genetic markers, lifestyle factors and his constitution to create a personalized prevention program.  Natural Medicine is not against conventional care, rather they should be in collaboration.  This is the common sense that is not so common, and the “thinking different” that is more cutting edge than mainstream oncology.   

Fear of untimely and miserable death from cancer complications is a big part of having cancer.  This   can lead patients to make emotional decisions about invasive and toxic treatments which don’t involve a lot of common sense.  An example of this was a patient who called me with invasive breast cancer.  She wanted to do natural treatments first, and then if that didn’t work, have surgery later.  I told her that she was getting the order wrong.

The knowledge needed to make decisions in this environment is benefited by understanding the literature of conventional and non-conventional cancer treatments.   Treating cancer is about the specifics of the situation.   Below are three examples of ways where oncology standards of care can be questioned, and where natural medicine works with conventional drugs in specific situations.  
  • Herceptin, a drug used for Her2 Neu over-expression: Olive oil polyphenols was found to increase the effectiveness of the drug significantly.  link here.
  • Cisplatin:  Astragalus-based herbal formulas help ameliorate toxic side effects of  without blocking effectiveness of the drug, according to the Journal of Clinical Oncology. link here
  • Tamoxifen:  Some women do not have proper activity of the CYP2D6 liver enzymes to convert Tamoxifen into its active form yet are prescribed it anyway. link here.  There are natural medicine protocols for women who won't derive benefit from Tamoxifen.  
There are other examples in which completely non-pharmaceutical approaches may be appropriate, particularly in slow growing cancers and in stage IV disease when the goal is palliation of symptoms, rather than cure. 
I do not blame Steve Jobs’ acupuncturist for leading him astray down a natural medicine path that would eventually kill him.  I am confident that Mr. Jobs had a unique and willful personality that he brought to his personal care in the same way he brought his ability to “Think different" to his career.

Wednesday, July 20, 2011

One Of The Most Researched Herbs - Curcumin

Curcumin is one of the most important well-researched cancer fighting herbs known.  It is a spice (think curry) and in its extract form a dye.  Plants with remarkable colors generally have potent medicinal properties.  Curcumin is an extract of Tumeric.  For health promotion and disease management it is best to have the highest potency curcumin extract.


A search of Medline reveals more than 1,500 studies describing the various activities of turmeric/curcumin.  What is it about curcumin that has so many scientists excited? The starting point is inflammation  but it is a whole lot more than that.  Inflammation is known to play a major role in the development of most diseases including: Cardiovascular diseases, Cancer, Pulmonary diseases, Neurological diseases (including Alzheimers), Autoimmune diseases, Arthritis and Diabetes.

Curcumin for a cancer patient is safe to take, acts as a chemotherapy and radio sensitizer while protecting normal cells.   It has multiple targets to down-regulate cancer growth pathways across multiple cancer types.  Cucumin has been found to suppress, retard, and even reverse cancer development at each stage of the disease. 

I recommend high potency extracts of curcumin in formulas as part of my base program for nearly all patients with cancer.   Curcumin needs to be taken with a little fat to help it absorb.  It can cause gas and intestinal upset at high doses. 

The following chart shows all the cancer targets that are up and down-regulated by curcumin.  If you think about drugs having usually 1 sometimes a few cancer targets, curcumin looks amazing for its 80 anti-cancer targets.   Curcumin (and herbs in general) are for me a part of the personalization of cancer treatment.   Finding in a particular tumor what is under or over-expressed and using herbs alone or in concert with drugs to treat cancer in a collaborative and intelligent manner.

I found the link to this chart in a 76 page paper called Curcumin: Indian Solid Gold. 


Bharrat Aggarawal is the prolific and innovative superstar in curcumin research.  Read an interview with him here.

For me Curcumin is part of what gives hope to treat and manage cancer.  Don't leave home without it.

Friday, October 29, 2010

The Safe and Efficacious Use of Chinese Herbs for Radiotherapy Patients (Part II)

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Life Cycle Health Center
The Safe and Efficacious Use of Chinese Herbs for Radiotherapy Patients (Part II)

Dear Doctors, Nurses, Caregivers, Patients and Friends:

In part I  Alex Berks, licensed acupuncturist and Clinical Director of Oncology for Life Cycle Health Center discussed the ways in which Chinese herbs can be used to treat some of the more troubling side effects of radiotherapy. In Part II we'll look at how Chinese herbs have been shown to enhance the effectiveness of radiotherapy.

A tumor's sensitivity to radiation is partly dependent on blood supply and oxygenation of the tissues. Herbs can improve both.  It has been reported that tumors have a ratio of anoxic cells that have poor radiation sensitivity and that radiotherapy may reach only about 1/3 of cells in a low oxygenic state. Low tumor infiltration by radiation is considered one of the factors causing tumor relapse.  

In Chinese medicine, herbs are generally prescribed in formulas, with modifications based upon the individual's unique presentation. In tailoring herbal formulas to the patient it is said that in Chinese medicine "the patient is treated". This contrasts with biomedicine's focus on cellular pathology, which leads to an approach by which "the disease is treated." Curiously, as biomedicine advances, it is resembling Chinese medicine more and more in providing specific treatments that are individualized to the unique presentation and characteristics of patients' tumors.

Research conducted on single herbs, though not representative of how Chinese herbs are most beneficially and clinically applied, illustrates the efficacy and principles of more complex herbal formulas.  An example of this is a study on a Liguistrazine extract of the common Chinese herb Chuan xiong (Radix Liguistici Wallichi). (See link at top, right.) This herb is known in the Chinese pharmocopeia as a blood activator.  It has anti-platelet, anticoagulant and blood vessel dilating properties.  It has also been researched for its ability to increase blood perfusion in the brain.  

Results of an animal study with this herb showed that rats responded to the herbal extract with increased microcirculation in caliber, flow speed, flow status and capillary count.  It is not hard to see that a formula with liguistici could improve the microcirculation of peri-tumor tissue and the tumor body, increase blood perfusion in the tumor body, improve cell's anoxic state and elevate the sensitivity of tumor tissue to radiotherapy.

The studies cited at right demonstrate the value of Chinese Herbal Medicine (CHM) in conjuction with radiotherapy (RT) to improve survival rates, lessen the impact of depletion of white blood cells, and improve a patient's ability to finish the full course of radiotherapy treatment. These findings imply that Chinese herbal medicine could enhance the radiosensitivity of tumors.   

In summary, Chinese herbal medicine can be combined efficaciously and safely to enhance radiotherapy's efficacy, improve and prevent side effects of treatment, as well as preserve long term vitality and survival.  

To achieve maximum benefit, patients should commence herbal treatment 1 week before starting radiotherapy and continue for at least 6 months after treatment. 

Please consult with a trained Chinese Medicine practitioner who is knowledgeable in the integrative support of cancer recovery, such as our team at Life Cycle Health Center.
In good health,
Alex Berks, L.Ac., Clinical Director, Oncology and
Ellen Rudolph, Executive Director,
Life Cycle Health Center

Research, Sources, and Viewpoints: Chinese Herbs to Enhance Radiotherapy

1. A 3-part study, "Traditional Chinese Medicine in the Treatment of Breast Cancer" by Isaac Cohen, LAc, OMD, Mary Tagliaferri, MD, LAc & Debu Tripathy, MD includes herbs that are commonly used in radiation such as Chuan Xiong  Read the article >>


2. Another excellent resource is: "Integrating Conventional and Chinese Medicine in Cancer Care: A Clinical Guide"

 (Churchill Livingstone Elsevier, 2007) by Tai Lahans, MTCM, M.Ed., L.Ac., a Chinese medicine cancer specialist with over 20 years of experience, practicing in Seattle; Read excepts>> scroll to page 119 for information on Chinese herbs and radiotherapy.

Book excerpt: "The purpose of XRT is to kill local and regional cancer cells mainly by making cell-damaging free radicals. Antioxidants, and by extension Chinese herbs that clear heat, are thought to possibly inhibit radiation from having its full effect. The scientific data shows that, counterintuitively, antioxidants, and by extension Chinese herbal formulas that clear heat and nourish yin, actually improve the efficacy of both chemotherapy and XRT. There is no current evidence that herbal medicines will decrease the effect of XRT. ...The vast evidence from research regarding herbal medicine and antioxidant therapies during radiation show that especially blood-regulating herbs like dan shen enhance the effectiveness of radiation."

3. "Breast Cancer and Botanical Medicine", a June 2008 article by Steven Gomberg, L.Ac., CCN, RH (AHG) and Brandon Horn, PhD, JD, L.Ac. provides a context and clinically relevant information on the use of herbs in the treatment of berast cancer. Read the article >>

Article excerpt: "...given the wealth of historical information on the safety and efficacy of various herbs (some of them having been used for thousands of years), an herbal regimen could be considered as an additional and potentially effective tool in the treatment of breast cancer." "By utilizing herbs that have both historical data and modern research demonstrating potential mechanisms for efficacy, it is possible to maximize the chances of favorable outcomes while minimizing discomfort associated with conventional therapies."  "...a lack of data on the combined effects of herbs and drugs should not necessarily be a hindrance to their use. The same prudent monitoring that allows for widespread use of untested pharmaceutical combinations can enable us to successfully apply the combined use of herbs and pharmaceuticals. With proper monitoring, herbs can be a substantial asset both in the treatment and prevention of breast cancer." 

The information in this newsletter is not a substitute for professional medical advice. You should not use this information to diagnose or treat a health problem or disease without consulting with your doctor. 

Sunday, May 03, 2009

Chinese Herbs for Cancer

Alex Writes: This article is a good overview of the TCM approach to cancer treatment.


Chinese herbalists have been medicating patients with tumors for over two

thousand years. 1 In stark contrast to Western oncology concepts that undergo

constant revision, Chinese medical ideas about tumor pathogenesis and herbal

responses have remained largely the same over the centuries.2 Still, though,

Traditional Chinese Medical (TCM) approaches hold strong attraction for human

oncology patients and people whose animals have cancer.3 TCM practitioners

shun the image of “waging war on cancer” and instead embrace the more

peaceful and organic view of cancer as a journey, regarding the patient not as a

battlefield but as a garden to be nurtured.4 5 6

The enormous draw of Chinese medicine and other traditional medicine practices

led the World Health Organization to consider ways to best study the

effectiveness and safe implementation of CAM methods in clinical practice. In

response, they formulated the Traditional Medicine Strategy 2002-2005.7 In the

same year, the White House Commission published a Complementary and

Alternative Medicine Policy.8 Both organizations urged researchers to

investigate the claims and practices of long-held belief systems and empirically

derived treatments. The National Cancer Institute now recognizes that

following the leads laid by longstanding tradition will generate higher yields than

searching for cancer-fighting botanicals de novo.9 Even the Chinese Society of

Traditional Veterinary Science in Taiwan and the Asian Society of Traditional

Veterinary Science have sounded calls for more research and education in

Traditional Chinese Veterinary Medicine (TCVM) and, specifically, in herbal

prescribing.10

The assortment of Chinese herbal treatments being promoted for animal patients

with cancer is growing. Testimonials asserting reductions in tumor size in dogs

who received Chinese herbs further stoke enthusiasm and hopes of finding an

alternative cure.11 12 13 However, rather than basing the herbal prescription on

tumor type or biopsy results, herbs are matched to a patient’s disease “pattern”,

which sorts patients into groups according a system based on visible signs on

the body, the specifics of which are unique to TCM.14

TCM holds that tumors and cancer arise from emotional stress, overwork, poor

nutrition, invasion of pathogens, and poor circulation.15 16 Of these, impaired

circulation ranks as perhaps the most strongly linked etiologic factors leading to

cancer and metastasis.17 18 From a Chinese medicine perspective, the poor

circulation associated with the “blood stasis” pattern will not only deprive tissue of

vital oxygen, absorbed nutrients, and immune surveillance, and it also leads to

the buildup of metabolic end-products in the tissues. Modern oncology resonates

with this perspective at least in part, acknowledging that the microcirculation

within tumors can be abnormal and contain areas of sluggish perfusion.

Furthermore, some researchers have added anticoagulants to chemotherapy

agents in order to lengthen survival and prevent blood-borne metastasis.19

Friday, October 19, 2007

DO HERBS, VITAMINS, AND ANTIOXIDANTS ADVERSELY AFFECT CANCER THERAPIES?

preliminary report by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon

For more than 30 years now, Chinese herbs and materials derived from the herbs, such as long chain polysaccharides, have been used as adjunct therapies for cancer patients. This modern application was first developed clinically in China and Japan during the 1970s and was relayed to the rest of the world in 1983 through an international conference in Beijing which was followed up by press reports in English and other languages (see: Physiological responses to immunologically active polysaccharides). The Institute for Traditional Medicine (ITM) made an effort to alert practitioners of Chinese medicine in the U.S. to this promising role for Chinese herbs immediately after that conference, with updated information provided as available over the years. The utilization of Chinese roots, leaves, and fruits (e.g., astragalus, gynostemma, ligustrum, and lycium), and several mushrooms (e.g., coriolus, ganoderma, cordyceps, and lentinus) for cancer patients is now a routine procedure when these patients visit acupuncturists, naturopathic physicians, and others offering adjunctive cancer health care.

Within the past couple of years, however, an increasing number of patients have been told by their oncologists to avoid herbs, and to more generally avoid supplements (such as vitamins), or, even more broadly, simply avoid anything with antioxidant potential while they are undergoing cancer therapies. The admonition itself is difficult to interpret, since all foods contain antioxidants and vitamins, and they also contain most of the other substances offered in dietary supplements. Most fruits, vegetables, beans, and nuts differ only slightly from herbs. A more specific recommendation is needed. But first, the question arises: why are doctors giving these instructions? What kind of information is being released to the public?

For the rest of the article click on the title of the article

Tuesday, August 07, 2007

Complementary Medicine and Cancer

WebMd.com seems to really like acupuncture based on the idea that it can do very little (to no) harm and has some positive research. The complex topic of herbs with cancer they do not look on favorably. This is not surprising given the fact that there is so much misinformation and fear/caution about herbal treatments with cancer patients. When I work with a cancer patient I am communicating with the patients' doctor so as not to interfere with conventional treatment and keep the Dr. apprised of what may be helping the patients. There are however, many "non-interfering" periods of cancer treatment where complimentary can be of use.


Acupuncture can be used nearly all the time. Although there is a theoretical caution about using acupuncture when white blood cell counts are low due to possible risk of infection.

Herbs, supplements can be used for a cancer patient safely when prescribed properly in all the following situations
  • Before and during intervals of conventional treatment
  • When a patient is not receiving treatment
  • During conventional treatment to relieve side effects. The research seems mostly weak describing ways to take supplements to improve chemotherapy treatment efficacy.
  • pre surgery preparation, recovery from surgery
  • Post treatment side effects
  • prevention
Treating a cancer patient with herbs and acupuncture is not just about treating cancer. By law I am not allowed to do this. However, within the diagnositic scope of my License as a California Acupuncturist I diagnose blood stagnation, phlegm accumulation, organ imbalances and other variations. The remarkable thing is that this approach to balancing the body that is germane to Chinese Medicine has tremendous benefit to patients and has for a very long time. While the oncologist tends to be focused on disease, I am focused on balancing the patient. Both have a place in the care of cancer patients. Alex


Also called alternative medicine, is the complementary approach a new model for Western medicine?
By R. Morgan Griffin
WebMD Feature
Reviewed by Louise Chang, MD

A few years ago, if you asked your oncologist for a referral to a masseuse, she'd think you were joking. But things have changed. Nowadays, your oncologist might be prescribing the massage -- along with acupuncture, herbs and other therapies.

It's a sign of a new trend: complementary medicine (also called integrative medicineintegrative medicine) is making its way into the mainstream, combining standard medical treatments with complementary ones. Some hospitals have even set up entire integrative medicine centers -- largely because of patient demand.

"Patients love it," says Simone Zappa, RN, an administrator in the Integrative Medicine Department at Memorial Sloan-Kettering Cancer Center in New York. "And they love it because it works."

Complementary treatments help many people with cancer. Massage, acupuncture, and hypnosis are being used along with radiation, chemotherapy, and surgery. These complementary therapies aren't usually intended to treat the cancer itself. But they can ease side effects and improve quality of life. They may even reduce the amount of medicine you need for treatment.

What's more, some of these treatments have been shown to work in scientific studies. The gulf between evidence-based Western medicine and traditional therapies is not as wide as it once was. And many people with cancer are benefiting.

Understanding Complementary Medicine

Complementary medicine includes dozens of treatments that have not been generally used in Western medicine. They extend from nutritional changes, to biofeedback, to yoga.

Experts stress that complementary or integrative medicine is not the same as "alternative medicine." Complementary medicine for cancer is a complement -- not a replacement -- for traditional treatments like radiation, chemotherapy, and surgery. It's an important distinction, since only conventional therapies have been shown to fight cancer.

People with cancer seek out complementary medicine for many reasons. Zappa says that, at Sloan-Kettering, she most often sees people suffering from pain, nausea, depressiondepression, anxiety, and fatiguefatigue. Some are wary of the unusual approach at first. But most are convinced after they try it, says Zappa. "What's great about the integrative approach is that it gives back a feeling of control."

Complementary Medicine's New Converts

For hardened skeptics, phrases like "traditional healing techniques" and "alternative medicine" conjure up images of magic crystals and the smell of incense. But in fact, the people researching complementary medicine -- and sometimes even practicing it -- are likely to be wearing lab coats.

"The people doing this work are not crackpots," says Heather S. Shaw, MD, co-director of the Integrative Oncology Program at Duke University. "I'm an oncologist and I spend a lot of my time parked on a laboratory bench doing research."

Indeed, hospitals with complementary medicine divisions are spearheading research. Experts are using the same rigor in evaluating complementary therapies that they would in testing drugs or surgery. It's not enough to assume that a treatment works just because it's been used for thousands of years. Doctors want evidence.

After seeing the benefits of complementary medicine, many doubting oncologists have been convinced.

"My colleagues used to think I was nuts," Shaw says. "They teased me about prescribing so-called 'herbs and spices'." But now her fellow doctors are always asking her advice on new ways to help their patients.

The Integrative Approach: Is It Proven?

Of course, here's the big question: do we know if complementary medicine really works?

The answer: It depends on the specific treatment. Acupuncture and massage -- which not so long ago were considered pretty far-out -- have been shown to help. Many studies have shown that acupuncture eases chemotherapy nausea, while other studies suggest acupuncture and massage may reduce pain from cancercancer or its treatment.

"A lot of oncologists don't see acupuncture or massage as 'alternative medicine' anymore," says Shaw. "These therapies are so well established that they've become standard."

Other complementary techniques aren't as well researched. So when a treatment is unproven, the question is whether its potential benefits outweigh its risks. If it's risky, it isn't used. But if the risks are very, very low, doctors may be more open.

"If a treatment is safe but unproven, why not give it a try if the patient is interested?" says David S. Rosenthal, MD, medical director of the Center for Integrated Therapies at the Dana Farber Cancer Institute.

Things get trickier with herbal and botanical supplements. Despite their wide popularity, few have been shown to be either safe or effective against cancer. On the other hand, some have been shown to be both ineffective and unsafe. One example is laetrile, which contains a substance found in the pits of some fruits. The active ingredient seems to be cyanide, and it has resulted in symptoms of cyanide poisoning. Some common supplements -- like St. John's wort and high doses of vitamin C -- can interact with chemotherapy and radiation.

"You have to be very careful with botanical and herbal supplements," says Zappa. "They are real drugs and we just don't know a lot about them." She hopes future research will show benefits. But for now, she and other experts urge caution. Given the risks, your doctor must know about all of the herbs, botanicals, and supplements you use.

Will My Insurance Pay for Complementary Medicine?

By and large, insurance companies don't cover complementary care. Specifics vary with each insurer and from state to state. For instance, acupuncture is covered in some states but not others, says Rosenthal.

For now, most complementary medicine is provided on a fee-for-service basis. But advocates of integrative medicineintegrative medicine say this is likely to change.

"A lot of us are doing research now that, we hope, will show the benefits of these therapies," says Rosenthal. "Once we have the evidence, we can make a case to the insurance companies."

Shaw agrees. "We're hoping to show that these treatments will actually save insurers money," she says. "They may reduce hospitalizations and drug costs."

Finding a Complementary Medicine Caregiver

A lot of people may offer "complementary medicine." But how do you know if they're reputable? It's hard to be sure.

You're lucky if you live near a teaching hospital with a complementary or integrative medicine center. Many offer complementary services right in the hospital. If you're not close to such a center, talk to your doctor. He or she may know of people practicing complementary medicine in your area.

You should also look for credentials. For instance, acupuncturists should either have an LAc or be a Doctor of Oriental Medicine, says Shaw. You can see if your state licenses acupuncturists and other providers. The National Center for Complementary and Alternative Medicine has tips for finding qualified caregivers.

Shaw has two rules of thumb when judging good complementary medicine providers. First, they will not make any claims to cure cancercancer. Second, they will not try to convince you to stop conventional therapy. If a practitioner does either, you should find someone else.

There's also the flip side. If you are interested in complementary therapies, it's important your oncologist be open to them. Not every doctor is. Some flat out demand that their patients stop using all complementary therapies, since they don't know enough about them, says Shaw.

"If you want complementary therapies and your oncologist is adamantly opposed to them, you might want to find someone else," says Shaw. "There are a lot of open-minded oncologists out there who will help you."

But Zappa predicts that opposition to integrative medicine will become more and more rare.

"People in medicine are scientists, and scientists rightly need proof that treatments work," she tells WebMD. "But now we finally have a lot of good research coming out. Once the research is out there, no one can ignore it. These treatments really do help people feel better."

WebMD Feature

Published Oct. 23, 2006.SOURCES: American Cancer Society web site, "Complementary and Alternative Therapies." Corbin, L. Cancer Control, July 2005; vol 12: pp 158-164. Memorial Sloan-Kettering Cancer Center web site, "Individual Therapies." National Cancer Institute, "Acupuncture PDQ," "Complementary and Alternative Medicine in Cancer Treatment: Questions and Answers." David S. Rosenthal, MD, professor of medicine, Harvard Medical School; medical director, Leonard P. Zakim Center for Integrated Therapies at the Dana Farber Cancer Institute, Boston. Heather S. Shaw, MD, assistant professor of medicine, Multidisciplinary Breast Program, Duke University Medical Center. Simone Zappa, RN, administrator, Integrative Medicine Department, Memorial Sloan-Kettering Cancer Center, New York. U.S. Department of Health and Human Services, "Thinking about Complementary and Alternative Medicine."
©2005-2007 WebMD, Inc. All rights reserved.
WebMD does not provide medical advice, diagnosis or treatment.

Monday, July 23, 2007

Classic Chinese Herbal Formula Increases Hematopoietic Stem Cells In a Mouse Model

This study demonstrates that the classic chinese herbal formula Xue Fu Zhu Yu Tang (Remove Stasis from the blood mansion) increases hematopoietic stem cells. In TCM terms this formula activates blood and has many uses for patterns of blood stagnation. Modifications of this formula could really be of use for folks that are suffering from bone marrow suppressed anemias. Good to know. Alex

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Jun;27(6):527-30.LinkOut

[Experimental study on effect of xuefu zhuyu decoction on bone marrow hematopoietic stem cells of mice]

[Article in Chinese]

Fujian College of Traditional Chinese Medicine, Fuzhou.

OBJECTIVE: To investigate the effect of Xuefu Zhuyu Decoction (XFZYD) on the number, phenotype, cell cycle and colony formation of bone marrow hematopoietic stem cells (HSC) in mice. METHODS: Kunming mice were randomly divided into 4 groups: the control group, the low- (3.25 g/kg), middle- (6.5 g/kg) and high-dose (13.0 g/kg) XFZYD groups. After they were medicated by gastrogavage respectively with saline or corresponding dose of XFZYD for 7 days, their bone marrow HSC were separated and counted. The phenotype Sca and cell cycle of HSC were detected by flow cytometer, and the colony formation was determined with semisolid methyl media culture. RESULTS: No obvious difference in the number of mononuclear cell, suspended cell and colony production was found among all the groups (P > 0.05); while the expression of CD34 and Sca-1 increased in the low-dose XFZYD group, but in the middle-dose XFZYD group increase only showed in Sca-1 expression. CONCLUSION: XFZYD plays a role of removing blood stasis and promoting regeneration through improving hematopoietic function by means of increasing the number and enhancing the function of premature HSC.

PMID: 17633366 [PubMed - in process]

Sunday, July 22, 2007

Herbal Aids for Cancer Review of 7 Herbs That Act As Biological Response Modifiers

The way I make an herbal formulas for a cancer patient is to integrate Western biochemical knowledge about herbs combined with traditional understandings of the herbs. This is done for at least 2 reasons. First it is not enough to just use a single herb or group of herbs for their effects on a certain chemical messenger or part of the immune system. This is incomplete. What happens if that herb is very warm propertied and the patient has a lot of heat to start with so to give that kind of herb would be making a bad situation worse. TCM's (traditional Chinese Mediicne) goal is to balance the body, by nudging the body towards balance the homeostatic mechanisms of the body - all of them - stand a better chance of working more effectively and efficiently. There are exceptions to this where an imbalanced formula can be of benefit. Second, in Chinese Medicine herbs work synergestically together. Chinese medicine's approach is to create harmony within the body systems. Good Chinese medicine is not about reducing herbs to an active ingredient and then extracting that. This inherently leads to imbalances or said another way strong effects and strong side-effects

Also TCM formulas take into account the dynamic balance of the individual. So even if there are strong and possibly toxic anti-cancer herbs there will also be herbs to support assimilation, combat the toxicity and regulate the dynamic balance of the body. The proof of this strategy being effective for a cancer patient can be measured in many ways depending on the situation. The main ways I think about it are quality of life, increase in longevity, less side effects from conventional treatment and better response to conventional treatment. This really is my message about treating cancer patients.

Alex

Herbal Aids for Cancer Review of 7 Herbs That Act As Biological Response Modifiers

Cancer treatments are a paradox, on one hand delivering powerful toxicity to a tumor, but on the other spreading toxicity to the rest of the body. The side effects of such treatments may cause death even before the cancer does. Biological response modifiers (BRMs) are compounds that have a unique effect on physiology and can reduce the side effects of cancer treatments, while at the same time increasing their effectiveness.

A BRM repairs damage to the body rather than targeting a pathogenic agent such as cancer. It typically acts by stimulating the immune system to restore optimal function. Many diseases and infections as well as AIDS result from immune surveillance failure. Because chemotherapy compromises the immune system, people receiving cancer treatments run an especially high risk of contracting and dying of infections.

Cytokines, hormones naturally produced in the body, promote immunity and are often used clinically as BRMs—to treat disease, fight viral infections and augment chemotherapy. Three pharmaceutical cytokines currently in use include colony-stimulating factors that reduce the chance of infection and thus the need for antibiotics by stimulating bone marrow to produce more white blood cells; interferons that stimulate macrophages to ingest foreign particles and help the body produce antiviral chemicals; and interleukins that stimulate growth and activation of white blood cells. The therapeutic use of these cytokines, called immunotherapy, as a cancer treatment both with and without standard anti-cancer drugs is marginally successful. Side effects such as depression, nausea and chest pain, however, can limit the effectiveness of some pharmaceutical cytokines.

Many herbs have long been known to affect the immune system, but only recently have scientists considered them as possible BRMs and adjunct cancer therapies. Such herbs often prompt the body's cells to secrete cytokines, which then enhance the immune response. The most promising of these herbs include black cumin, mistletoe, ginseng, astragalus, green tea, echinacea and garlic.

Saturday, July 21, 2007

Complimentary cancer strategies an idea

When developing complimentary strategies to treat cancers one way is to understand the action of the drug used to treat it and then look at research into nutrients/supplements and herbs that work on the same cell signalling pathways. An example of this approach is the drug Lapatinib. It works upon the cell signaling proteins that are over-expressed in certain kinds of cancer cells. To be exact, according to Wikipedia, Lapatinib is an epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor.

Lapatinib (INN) or lapatinib ditosylate (USAN), also known as GW572016, is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug Capecitabine (Xeloda TM). It is marketed by GSK in the U.S. as Tykerb and in Europe as Tycerb.

Lapatinib is a once-daily oral drug indicated for women who have received prior treatment with the intravenous drug Trastuzumab (Herceptin TM) and cancer drugs called taxanes and anthracyclines. [1]

In patients with HER2+ metastatic breast cancer that has progressed following treatment with regimens that included an anthracycline, a taxane, and trastuzumab; randomized clinical trial has demonstrated that the addition of lapatinib to capecitabine delayed the time of further cancer growth compared to capecitabine alone.

What if there are natural products that could have similar action?

Here are some links to herbs that work on the same and additional cell signalling pathways to Lapatinib:

Adv Exp Med Biol. 2007;595:1-75.Links

Curcumin: the Indian solid gold.

Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN). Considering the recent scientific bandwagon that multitargeted therapy is better than monotargeted therapy for most diseases, curcumin can be considered an ideal "Spice for Life".


Curr Oncol. 2006 Jun;13(3):99-107.Click here to read Links


Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2.

Juravinski Cancer Centre and McMaster University (Department of Medicine), Hamilton, Ontario.

The herbalist has access to hundreds of years of observational data on the anticancer activity of many herbs. Laboratory studies are expanding the clinical knowledge that is already documented in traditional texts. The herbs that are traditionally used for anti-cancer treatment and that are anti-angiogenic through multiple interdependent processes (including effects on gene expression, signal processing, and enzyme activities) include Artemisia annua (Chinese wormwood), Viscum album (European mistletoe), Curcuma longa (curcumin), Scutellaria baicalensis (Chinese skullcap), resveratrol and proanthocyanidin (grape seed extract), Magnolia officinalis (Chinese magnolia tree), Camellia sinensis (green tea), Ginkgo biloba, quercetin, Poria cocos, Zingiber officinalis (ginger), Panax ginseng, Rabdosia rubescens hora (Rabdosia), and Chinese destagnation herbs. Natural health products target molecular pathways other than angiogenesis, including epidermal growth factor receptor, the HER2/neu gene, the cyclo-oxygenase-2 enzyme, the nuclear factor kappa-B transcription factor, the protein kinases, the Bcl-2 protein, and coagulation pathways. Quality assurance of appropriate extracts is essential prior to embarking upon clinical trials. More data are required on dose-response, appropriate combinations, and potential toxicities. Given the multiple effects of these agents, their future use for cancer therapy probably lies in synergistic combinations. During active cancer therapy they should generally be evaluated in combination with chemotherapy and radiation. In this role, they act as modifiers of biologic response or as adaptogens, potentially enhancing the efficacy of the conventional therapies or reducing toxicity. Their effectiveness may be increased when multiple agents are used in optimal combinations. New designs for trials to demonstrate activity in human subjects are required. Although controlled trials may be preferable, smaller studies with appropriate endpoints and surrogate markers for anti-angiogenic response could help to prioritize agents for larger, resource-intensive phase iii trials.


Friday, July 06, 2007

Chinese medicinal herbs inhibit growth of murine renal cell carcinoma.

Tumors are known to produce factors suppressing immune functions. We previously showed that a murine renal cell carcinoma (Renca) suppressed macrophage function in vitro and that this suppression was abolished by co-incubation with extracts of two Chinese medicinal herbs. We now report that these phytochemicals are capable of inhibiting growth of Renca in vivo. BALB/c mice were transplanted intraperitoneally (IP) with 1-2 x 10(5) Renca cells. One day after tumor transplant, mice were randomized into two groups. One group was treated IP, daily for 10 days, with 100 microliters of phytochemicals containing 500 micrograms each of Astragalus membranaceus and Ligustrum lucidum, while the other group received saline as controls. A cure rate of 57% was obtained with these phytochemicals when the initial tumor load was 2 x 10(5), and 100% when the initial tumor load was 1 x 10(5). Additional experiments were performed to investigate the mechanisms involved in this protection. Splenic macrophages from tumor-bearing mice were shown to have depressed chemiluminescent oxidative burst activity, and this depression was restored with phytochemical treatment. Splenocytes from mice transplanted with Renca responded less favorably to interleukin-2 (IL-2) in generating lymphokine-activated killer (LAK) cells; again this depression was restored with phytochemical treatment. Our data suggest that these phytochemicals may have exerted their antitumor effects via augmentation of phagocyte and LAK cell activities.

Cancer Biother. 1994 Summer;9(2):153-61.Links

Department of Microbiology, School of Medicine, Loma Linda University, California 92350.

Monday, June 04, 2007

American Ginseng Shows Potential to Reduce Cancer Related Fatigue

Science Daily — North Central Cancer Treatment Group (NCCTG) researchers, based at Mayo Clinic in Rochester, Minn., have generated preliminary data suggesting that a form of American ginseng provides greater improvements in fatigue and vitality in patients who receive the highest doses tested, compared to lower doses or no treatment.


American ginseng. (Credit: iStockphoto/Mike Liu)

The results of their scientifically rigorous pilot study, the first to evaluate the Wisconsin species of American ginseng as a possible therapy for cancer-related fatigue, were presented June 3 at the annual meeting of the American Society of Clinical Oncology.

This press release goes on to explain how most Americans don't pick their herbs and supplements based upon scientific research. So with this study they are trying to shed some light. I Look forward to the full study. Of course those uniformed folks could always ask an expert. Send me an email. I'll answer it. Alex

Saturday, December 30, 2006

Essiac Tea Doesn't Show Much Promise

Several papers have been published on Essiac in the last few years and are worth noting.. One in particular is important because it suggests that using Essiac may be dangerous for patients with breast cancer.

Two papers are about Essiac and prostate cancer and are positive. In August 2004, the Journal of Alternative and Complementary Medicine published a test tube study that showed that Essiac might inhibit prostate tumor cell growth. [ii] The Canadian Journal of Urology published, in October 2005, an anecdotal report about a 64-year-old man with prostate cancer who did well while taking Essiac. [iii]

Thursday, December 21, 2006

Herbs and Nutrients with Anti-cancer Activity Abound

Here I go again: More natural substances that have research as being effective in cancer in a number of ways:
  • Promoting apoptosis (cell death)
  • Inhibiting the known pathways that cancers use to develop ie... VEG-F or NF kappa B, MMPs (and that many new cancer drugs work on)
  • Decreasing the side effects of toxic cancer drugs.
So here are a few I came across in the last day:

Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis.

This research is based on off the shelf nutrients available in probably any health food store.

The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line.

cordycepin is an extracted component of the chinese herb Cordyceps. I use it in my practice frequently to improve lung function.

Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells.

silibinin is an extracted component of Milk Thistle.

Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.

Baicalein is the exracted component of the chinese herb scutellaria huang qin. I use this herb frequently for many conditions.

If you click through to the links in the pubmed you will see numerous studies for each of the herbs and nutrients I have listed. The point is that there are many natural ways to prevent and treat cancer. This kind of stuff abounds. The use of these substances in the preventitive approach is relatively simple because everything listed here is non-toxic. How they may interact with on-going conventional therapy is another matter entirely that needs examination on a case by case basis.

Monday, December 18, 2006

Ganoderma aka Reishi mushroom effective in breast cancer treatment and prevention

2006 DEC 1 - (NewsRx.com) -- Research conducted in the United States has provided new information about breast cancer.

Study 1: Ganoderma lucidum (link to wikipedia) could be used as a suitable herb for chemoprevention and chemotherapy of breast cancer via down-regulation of estrogen receptor and NF-kappa B signaling...

The researchers concluded, "Collectively, these results suggest that G. lucidum inhibits proliferation of human breast cancer cells and contain biologically active compounds with specificity against estrogen receptor and NF-kappa B signaling, and implicate G. lucidum as a suitable herb for chemoprevention and chemotherapy of breast cancer."

Jiang and colleagues published their study in International Journal of Oncology (Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappa B signaling. Int J Oncol, 2006;29(3):695-703).